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Publication Open Access Validation of the Omni Scale of perceived exertion for cycle Ergometer exercise in young female: Thai Version(2555) นราวุฒิ นาคคนึง; เมตตา ปิ่นทอง; Dabayebeh, Ibrahim; รุ่งชัย ชวนไชยะกูล; Robertson, Robert; Narawut Nakkanung; Metta Pinthong; Rungchai Chuanchaiyakul; มหาวิทยาลัยมหิดล. วิทยาลัยวิทยาศาสตร์และเทคโนโลยีการกีฬา, L/min), minute ventilation (VE, L/min), respiratory rate (RR, b/min) and ratings of perceived exertion (OMNI cycle Scale; RPE) for the overall body (RPE-O), legs (RPE-L), and chest (RPE-C) were determined at the end of each of 3-min exercise stages...: 14.20-26.58 ml/kg/min; VE: 15.1-41.7 L/min; RR: 22.3-33.2 b/min and OMNI RPE RPE-O, RPE-L, and RPE-C: 0.8-7.1. Linear regression analyses showed that RPE-O, RPE-L and RPE-C distributed as a positive linear function for all criterion measures (HR, VO2Item Metadata only Fabrication of a versatile and efficient ultraviolet blocking biodegradable composite film consisting of Tara gum/PVA/Riceberry phenolics reinforced with biogenic riceberry phenolic-rich extract-nano‑silver(2024-10-01) Eze F.N.; Eze R.C.; Singh S.; Okpara K.E.; Eze F.N.; Mahidol UniversityThe demand for UV-protective and biodegradable packaging materials has been increasing with greater awareness about environmental sustainability and human safety. In this work, the effect of incorporating riceberry phenolic extract (RPE) as well... as combined RPE and green synthesized biogenic nano‑silver (RPE-NS, into Tara gum/PVA (TP)-based matrix was evaluated on the physical, mechanical, functional, biocompatible and biodegradable attributes of the resultant composite films. Integration of RPE (2 wtPublication Metadata only TNF-α-induced ICAM-1 expression and monocyte adhesion in human RPE cells is mediated in part through autocrine VEGF stimulation(2014-06-10) Peeradech Thichanpiang; Steven J. Harper; Kanokpan Wongprasert; David O. Bates; Mahidol University; University of Bristol; University of NottinghamPurpose: Local inflammation at the RPE cell layer is associated with inflammatory cell migration and secretion of proinflammatory cytokines such as tumor necrosis factor (TNF)-α. TNF-α upregulates intercellular adhesion molecule (ICAM)-1 expression... on the RPE, which allows lymphocyte function-associated antigen-1 (LFA-1) to bind on leukocytes that contribute to leukocyte adhesion at sites of inflammation. Vascular endothelial growth factor (VEGF)-A165b is generated by alternative splicing of VEGF-APublication Metadata only Integrated Microarray and RNAseq Transcriptomic Analysis of Retinal Pigment Epithelium/Choroid in Age-Related Macular Degeneration(2020-08-21) Dhanach Dhirachaikulpanich; Xin Li; Louise F. Porter; Luminita Paraoan; University of Liverpool; Faculty of Medicine, Siriraj Hospital, Mahidol University© Copyright © 2020 Dhirachaikulpanich, Li, Porter and Paraoan. We report for the first time an integrated transcriptomic analysis of RPE/choroid dysfunction in AMD (mixed stages) based on combining data from publicly available microarray (GSE29801... transcriptomic studies. The analysis highlighted 764 meta-genes (366 downregulated and 398 upregulated) in macular AMD RPE/choroid and 445 meta-genes (244 downregulated and 201 upregulated) in non-macular AMD RPE/choroid. Of these, 731 genes were newly detectedPublication Metadata only Green tea polyphenol epigallocatechin-3-gallate attenuates TNF-α-induced intercellular adhesion molecule-1 expression and monocyte adhesion to retinal pigment epithelial cells(2015-01-01) Peeradech Thichanpiang; Kanokpan Wongprasert; Faculty of Physical Therapy; Mahidol University, anticancer and anti-inflammatory properties. EGCG has been shown to protect retinal pigment epithelium (RPE) against oxidative stress-induced cell death. The pathogenesis of diseases in the retina is usually initiated by local inflammation at the RPE cell... layer, and inflammation is mostly associated with leukocyte migration and the secretion of pro-inflammatory cytokines. Whether EGCG can modulate the cytokine-induced inflammatory response of RPE, particularly leukocyte migration, has not been clearlyPublication Metadata only Secretory proteostasis of the retinal pigmented epithelium: Impairment links to age-related macular degeneration(2020-01-01) Luminita Paraoan; Umar Sharif; Emil Carlsson; Wasu Supharattanasitthi; Nur Musfirah Mahmud; Tengku Ain Kamalden; Paul Hiscott; Malcolm Jackson; Ian Grierson; University of Malaya; University of Liverpool; Mahidol University© 2020 Elsevier Ltd Secretory proteostasis integrates protein synthesis, processing, folding and trafficking pathways that are essential for efficient cellular secretion. For the retinal pigment epithelium (RPE), secretory proteostasis is of vital... importance for the maintenance of the structural and functional integrity of apical (photoreceptors) and basal (Bruch's membrane/choroidal blood supply) sides of the environment it resides in. This integrity is achieved through functions governed by RPEItem Metadata only Subjective and Physiological Correlations during Field-Based Soccer Training(2024-01-01) Kaewchuay S.; Onnom E.; Chaunchaiyakul R.; Masodsai K.; Kaewchuay S.; Mahidol Universityexertion (RPE, 10 scale) and physiologic variables that included heart rate (HR) and oxygen consumption (VO2) were assessed at rest and during the simulated first-half (3*15 min, S1, S2, and S3, of running, walking, jogging, and sprinting between 20-meter... increasing patterns of overall (first-and second-half) of RPE and HR with R2 = 0.336 (P < 0.001). The correlations between RPE and VO2, on the other hand, show the slightly higher but parallel increasing patterns of overall (first-and second-half), with R2Publication Metadata only RNA-seq analysis of ageing human retinal pigment epithelium: Unexpected up-regulation of visual cycle gene transcription(2021-06-01) Joe M. Butler; Wasu Supharattanasitthi; Yit C. Yang; Luminita Paraoan; New Cross Hospital; University of Liverpool; Mahidol University; Amsterdam UMC - University of AmsterdamAgeing presents adverse effects on the retina and is the primary risk factor for age-related macular degeneration (AMD). We report the first RNA-seq analysis of age-related transcriptional changes in the human retinal pigment epithelium (RPE...), the primary site of AMD pathogenesis. Whole transcriptome sequencing of RPE from human donors ranging in age from 31 to 93 reveals that ageing is associated with increasing transcription of main RPE-associated visual cycle genes (including LRAT, RPE65, RDH5Item Metadata only Intercellular communication analysis of the human retinal pigment epithelial and choroidal cells predicts pathways associated with aging, cellular senescence and age-related macular degeneration(2022-11-03) Dhirachaikulpanich D.; Mahidol UniversityThe retinal pigment epithelium (RPE) and the choroid are ocular tissues with fundamental roles in supporting neuroretinal function. The pathogenesis of age-related macular degeneration (AMD), a leading cause of irreversible blindness for which aging... as a potential driver of AMD. Here, we investigated the role played by intercellular communication in the RPE/choroid within the context of aging, senescence and AMD. We inferred cell–cell interactions in the RPE/choroid by applying CellChat and scPublication Metadata only Increased rate of retinal pigment epithelial cell migration and pro-angiogenic potential ensuing from reduced cystatin C expression(2020-02-01) Emil Carlsson; Wasu Supharattanasitthi; Malcolm Jackson; Luminita Paraoan; University of Liverpool; Mahidol Universitysecretion from retinal pigment epithelial (RPE) cells. Because cystatin C inhibits multiple extracellular matrix (ECM)–degrading cathepsins, this study evaluated the role of this mutation in inducing ECM-related functional changes in RPE cellular behavior.... METHODS. Induced pluripotent stem cells gene-edited bi-allelically by CRISPR/Cas9 to express the AMD-linked cystatin C variant were differentiated to RPE cells and assayed for their ability to degrade fluorescently labeled ECM proteins. Cellular migration