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Publication Metadata only Concomitant inheritance of α‐thalassemia in β°‐thalassemia/hb e disease(1985-01-01) Pranee Winichagoon; Suthat Fucharoen; David Weatherall; Prawase Wasi; Faculty of Medicine, Thammasat University; John Radcliffe Hospital; Mahidol UniversityConcomitant inheritance of α‐thalassemia in patients with β°‐thalassemia/hemoglobin (Hb) E disease was detected by restriction endonuclease DNA mapping. Among 42 patients with β°‐thalassemia/Hb E disease, seven were found to have an α‐thalassemia‐2... haplotype. Of these, five belonged to the rightward or 3.7‐kb type of α‐thalassemia‐2 and the remaining two the leftward or 4.2‐kb type. All the seven patients with α‐thalassemia‐2 haplotype had hemoglobin levels of 7.4 g/dl or above; those withoutPublication Metadata only Clinical Classification, Screening and Diagnosis for Thalassemia(2018-04-01) Vip Viprakasit; Supachai Ekwattanakit; Faculty of Medicine, Siriraj Hospital, Mahidol University© 2017 Elsevier Inc. At present, thalassemia diseases are classified into transfusion-dependent thalassemia and non–transfusion-dependent thalassemia. This classification is based on the clinical severity of patients determining whether they do... require regular blood transfusions to survive (transfusion-dependent thalassemia) or not (non–transfusion-dependent thalassemia). In addition to the previous terminology of “thalassemia major” or “thalassemia intermedia,” this classification has embracedPublication Metadata only Red cell parameters in alpha-thalassemia with and without beta-thalassemia trait or hemoglobin E trait(1997-12-01) Sumalee Jindadamrongwech; Raewadee Wisedpanichkij; Ahnond Bunyaratvej; Pongjan Hathirat; Sirikit Medical Center; Mahidol University; Faculty of Medicine, Ramathibodi Hospital, Mahidol UniversityEighty-five patients who attended at Ramathibodi Hospital during November 1994 to June 1996 were investigated for thalassemia genotype. hemoglobin (Hb) typing and blood cell parameters All patients were screened primarily for complete blood count... 45 cases out of 85 were α-thalassemia trait with A2A typing, 10 were normal, 7 were α-thalassemia trait complicated by β-thalassemia trait or HbE trait, 18 were HbH disease or HbH with Hb Constant Spring (HbH/CS), and 5 were AE Bart's disease. The αItem Metadata only In Vitro Study of Ineffective Erythropoiesis in Thalassemia: Diverse Intrinsic Pathophysiological Features of Erythroid Cells Derived from Various Thalassemia Syndromes(2022-09-01) Kaewsakulthong W.; Suriyun T.; Chumchuen S.; Anurathapan U.; Hongeng S.; Fucharoen S.; Sripichai O.; Mahidol UniversityDefective hemoglobin production and ineffective erythropoiesis contribute to the pathophysiology of thalassemia syndromes. Previous studies in the field of erythropoiesis mainly focused on the severe forms of thalassemia, such as β-thalassemia major..., while mechanisms underlying the pathogenesis of other thalassemia syndromes remain largely unexplored. The current study aimed to investigate the intrinsic pathophysiological properties of erythroid cells derived from the most common forms of thalassemiaItem Metadata only Characterization of proteins in microparticles from peripheral blood of thalassemia patients(Mahidol University. Mahidol University Library and Knowledge Center, 2009) Panida Kumya; Kovit PattanapanyasatItem Metadata only Predicting factors of survival rates among alpha- and beta-thalassemia patients: a retrospective 10-year data analysis(2024-01-01) Iam-arunthai K.; Suwanban T.; Thungthong P.; Chamnanchanunt S.; Fucharoen S.; Iam-arunthai K.; Mahidol UniversityBackground: Thalassemia is a genetic hemoglobinopathy in which a defective globin chain can cause transfusion-dependent anemia and other complications. As genotype interactions lead to variations in the clinical course among patients... with thalassemia, clinical factors may help predict survival in the types of thalassemia complicated by gene interactions. Aim: This study aimed to determine the clinical factors associated with survival in patients with thalassemia. We retrospectively reviewedItem Metadata only Pregnancy outcome of thalassemia(Mahidol University. Mahidol University Library and Knowledge Center, 2000) Paradee Chompookaew; Surapol Suwanagool; Jayanton Patumanond; Chamaiporn Tawichasri; Soysaang SethavanichItem Metadata only Production of chicken IGY antibodies specific for hemoglobin gamma-chain and mouse monoclonal antibody specific for hemoglobin bart's for thalassemia diagnosis(Mahidol University. Mahidol University Library and Knowledge Center, 2023) Pornrutsami Jintaridth; Ruchaneekorn KalpravidhPublication Metadata only Clinical and hematologic aspects of hemoglobin E β-thalassemia(2000-03-02) Suthat Fucharoen; Pranee Winichagoon; Mahidol UniversityHemoglobin E β-thalassemia is an important cause of childhood chronic disease in Southeast Asia. It is characterized by the presence of hemoglobin E and F, and the amount of hemoglobin E ranges from 35% to 75%. The patients are generally classified... as having thalassemia intermedia because they have inherited a β-thalassemia allele and hemoglobin E, which acts as a mild β+-thalassemia. However, a remarkable variability in the clinical expression, ranging from a mild form of thalassemia intermediaItem Metadata only Justification of Universal Iron Supplementation for Infants 6-12 months in Regions with a High Prevalence of Thalassemia(2023-01-01) Sinlapamongkolkul P.; Surapolchai P.; Viprakasit V.; Mahidol UniversityIntroduction: Many clinicians hesitate to adopt a universal infant iron supplementation program due to the risk of increased iron absorption for those with thalassemia. We aimed to determine thalassemia prevalence in 6- to 12-month-old infants..., along with the iron status of those with and without thalassemia. Methods: We performed a cross-sectional descriptive study of infants attending the Well Baby Clinic at Thammasat University Hospital for routine checkups. Complete blood count, hemoglobin