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Publication Open Access Determinants of tobacco smoking among presumptive TB patients in Taungoo Township, Myanmar(2017) Kyaw Hsan Tun; Seo Ah Hong; Jiraporn Chompikul; จอ ซาน ตุน; โซ อะ หงษ์; จิราพร ชมพิกุล; Mahidol University. ASEAN Institute for Health DevelopmentA hospital-based cross-sectional study was conducted in Taungoo Township, Myanmar to examine prevalence and determinants of current tobacco smokers among presumptive TB patients aged 18 years and above. A total of 400 presumptive TB patients which...). This study showed one in two presumptive TB patients were current smokers. Current smokers were particularly male, from low socioeconomic status and had poor knowledge, lived alone, drank alcohol, and had mental distress. This could help policy makersPublication Metadata only Evaluation of the GeneXpert MTB/RIF in patients with presumptive tuberculous meningitis(2018-06-01) Tatiana Metcalf; Jaime Soria; Silvia M. Montano; Eduardo Ticona; Carlton A. Evans; Luz Huaroto; Matthew Kasper; Eric S. Ramos; Nicanor Mori; Podjanee Jittamala; Kesinee Chotivanich; Irwin F. Chavez; Pratap Singhasivanon; Sasithon Pukrittayakamee; Joseph R. Zunt; Naval Medical Research Unit No. 6; Universidad Peruana Cayetano Heredia; Hospital Nacional Dos de Mayo; University of Washington, Seattle; Imperial College London; Mahidol UniversityXpert provided same-day rifampicin-susceptibility results, whereas culture-based testing took 32–71 days. 38% (3/8, 95%CI: 8.5–76%) of patients with definite TBM with data had evidence of drug-resistant TB, but 73% (22/30) of all clinically diagnosed TBM... approaches for diagnosing tuberculosis meningitis (TBM). Methods Patients were adults (n = 37) presenting with suspected TBM to the Hospital Nacional Dos de Mayo, Lima, Peru, during 12 months until 1st January 2015. Each participant had a single CSF specimenItem Metadata only Economic Evaluation of Molecular Testing for Pulmonary Tuberculosis Diagnosis: A Systematic Review(2025-01-01) Chitpim N.; Yoopetch P.; Jittikoon J.; Udomsinprasert W.; Bunwong K.; Mahasirimongkol S.; Chaikledkaew U.; Chitpim N.; Mahidol UniversityPurpose: Rapid molecular assays such as Xpert MTB/RIF and TB-LAMP accelerate pulmonary tuberculosis (TB) diagnosis but are more expensive than smear microscopy. This study provided an updated economic synthesis for presumptive adult pulmonary TB.... Conclusion: Recent evidence supports the cost-effectiveness and cost-saving of Xpert MTB/RIF and TB-LAMP for diagnosing adult pulmonary TB. Policymakers should prioritize reducing cartridge costs and implementing models that capture patient-level benefitsPublication Metadata only Prevalence and determinants of inappropriate antibiotic dispensing at private drug retail outlets in urban and rural areas of Indonesia: A mixed methods study(2021-08-03) Luh Putu Lila Wulandari; Mishal Khan; Marco Liverani; Astri Ferdiana; Yusuf Ari Mashuri; Ari Probandari; Tri Wibawa; Neha Batura; Gill Schierhout; John Kaldor; Rebecca Guy; Matthew Law; Richard Day; Johanna Hanefeld; Harry Parathon; Stephen Jan; Shunmay Yeung; Virginia Wiseman; Universitas Sebelas Maret; Universitas Udayana; Ministry of Health, Republic of Indonesia; Universitas Gadjah Mada; The Aga Khan University; London School of Hygiene & Tropical Medicine; UNSW Sydney; The Kirby Institute; University College London; Robert Koch Institut; Mahidol University; Nagasaki University; Faculty of Medicinevisits to 166 drug outlets (community pharmacies and drug stores) between July and August 2019. The SPs presented three clinical cases to drug outlet staff: parent of a child at home with diarrhoea; an adult with presumptive tuberculosis (TB...Introduction The aim of this mixed-method study was to determine the extent and determinants of inappropriate dispensing of antibiotics by licensed private drug retail outlets in Indonesia. Methods Standardised patients (SPs) made a total of 495Publication Open Access Prevalence and associated factors of non-uptake of human immunodeficiency virus testing of tuberculosis patients in Thailand(2015) Supa Pengpid; Karl Peltzer; Mahidol University. ASEAN Institute for Health Developmenttuberculosis (TB) patients from 42 public hospitals (21 provincial and 21 district hospitals), in 21 provinces, from all four regions in Thailand. All new TB and new retreatment patients were interviewed within one month of anti-tuberculosis treatment...”. In conclusion, the level of HIV testing among TB hospital patients was suboptimal, and the Ministry of Public Health should continue to scale-up HIV testing and other collaborative TB-HIV services at health facilities.Publication Open Access A case report of intravenous posaconazole in hepatic and renal impairment patient with invasive Aspergillus terreus infection: safety and role of therapeutic drug monitoring(2017) Pitchaya Dilokpattanamongkol; Panadda Panusitthikorn; Rasda Boonprasert; Methee Chayakulkeeree; Porpon Rotjanapan; Mahidol University. Faculty of Pharmacy. Department of Pharmacy; Mahidol University. Faculty of Medicine, Siriraj Hospital. Department of Pharmacy; Mahidol University. Faculty of Medicine, Siriraj Hospital. Clinical Toxicology Laboratory, Siriraj Poison Control Center; Mahidol University. Faculty of Medicine, Siriraj Hospital. Division of Infectious Diseases and Tropical Medicine.; Mahidol University. Department of Medicine, Ramathibodi Hospital. Division of Infectious DiseasesBackground: Invasive aspergillosis (IA) is a fatal infectious complication among immunocompromised patients. Aspergillus terreus, the fourth common species can be difficult to treat due to a unique resistance pattern. To date, there has been... no report on safety and dose adjustment when intravenous posaconazole is selected in hepatic and renal impairment patient. We present a rare case of intravenous posaconazole use in a hepatic and renal impairment patient with invasive A. terreus pulmonaryPublication Open Access A case report of intravenous posaconazole in hepatic and renal impairment patient with invasive Aspergillus terreus infection: safety and role of therapeutic drug monitoring(2017) Pitchaya Dilokpattanamongkol; Panadda Panusitthikorn; Rasda Boonprasert; Methee Chayakulkeeree; Porpon Rotjanapan; Mahidol University. Faculty of Pharmacy. Department of Pharmacy; Mahidol University. Faculty of Medicine, Siriraj Hospital. Department of Pharmacy; Mahidol University. Faculty of Medicine, Siriraj Hospital. Clinical Toxicology Laboratory, Siriraj Poison Control Center; Mahidol University. Faculty of Medicine, Siriraj Hospital. Division of Infectious Diseases and Tropical Medicine,; Mahidol University. Department of Medicine, Ramathibodi Hospital. Division of Infectious DiseasesBackground: Invasive aspergillosis (IA) is a fatal infectious complication among immunocompromised patients. Aspergillus terreus, the fourth common species can be difficult to treat due to a unique resistance pattern. To date, there has been... no report on safety and dose adjustment when intravenous posaconazole is selected in hepatic and renal impairment patient. We present a rare case of intravenous posaconazole use in a hepatic and renal impairment patient with invasive A. terreus pulmonaryPublication Open Access Prediction of difficulty in impacted lower third molars extraction; review literature.(2015-09) Latt, Maung Maung; Pruedy Chewpreecha; พฤทธิ์ ชิวปรีชา; Natthamet Wongsirichat; ณัฐเมศร์ วงศ์สิริฉัตร; Natthamet Wongsirichat; ณัฐเมศร์ วงศ์สิริฉัตร; Mahidol University. Faculty of Dentistry. Department of Oral and Maxillofacial Surgeryimportant factors, such as periodontal ligament width, soft tissue condition, patient characteristic, and clinician’s experience. Further clinical studies should be conducted for new classification to get more reliable evaluation and more useful for dailyPublication Open Access Aberrant antigenic expression in extranodal NK/T-cell lymphoma: a multi-parameter study from Thailand(2011) Tawatchai Pongpruttipan; Tanawan Kummalue; Anan Bedavanija; Archrob Khuhapinant; Koichi Ohshima; Fumiko Arakawa; Daisuke Niino; Sanya Sukpanichnant; Mahidol University. Faculty of Medicine Siriraj Hospital. Department of PathologyBackground: Extranodal NK/T-cell lymphoma, nasal type (ENKTL) is not common worldwide, but it is the most common T- and NK-cell lymphomas in many Asian countries. Immunophenotypic profiles were studied based on limited series. The authors, therefore, studied on ENKTL according to characterize immunophenotypic profiles as well as the distribution of EBV subtype and LMP-1 gene deletion. Methods: By using tissue microarray (TMA), immunohistochemical study and EBV encoded RNA (EBER) in situ hybridization were performed. T-cell receptor (TCR) gene rearrangement, EBV subtyping, and LMP-1 gene deletion were studied on the available cases. Results: There were 22 cases eligible for TMA. ENKTL were positive for CD3 (91%), CD5 (9%), CD7 (32%), CD4 (14%), CD56 (82%), TIA-1 (100%), granzyme B (95%), perforin (86%), CD45 (83%), CD30 (75%), Oct2 (25%), and IRF4/ MUM1 (33%). None of them was positive for bF1, CD8, or CD57. TCR gene rearrangement was negative in all 18 tested cases. EBV was subtype A in all 15 tested cases, with 87% deleted LMP-1 gene. Cases lacking perforin expression demonstrated a significantly poorer survival outcome (p = 0.008). Conclusions: The present study demonstrated TIA-1 and EBER as the two most sensitive markers. There were a few CD3 and/or CD56 negative cases noted. Interestingly, losses of CD45 and/or CD7 were not uncommon while Oct2 and IRF4/MUM1 could be positive in a subset of cases. Based on the present study in conjunction with the literature review, determination of PCR-based TCR gene rearrangement analysis might not be a useful technique for making diagnosis of ENKTL.