Jirapa ChetsawangPiyarat GovitrapongBanthit ChetsawangMahidol University. Institute of Molecular Biosciences. Research Center for NeuroscienceMahidol University. Faculty of Science. Center for Neuroscience and Department of PharmacologyMahidol University. Faculty of Medicine Siriraj Hospital. Department of Anatomy2015-08-102017-04-252015-08-102017-04-252015-08-102010Journal of Biomedicine and Biotechnology. 2010, ID 803815https://repository.li.mahidol.ac.th/handle/20.500.14594/1830It has been reported that overproduction of reactive oxygen species occurs after brain injury and mediates neuronal cells degeneration. In the present study, we examined the role of Ras signaling on hydrogen peroxide-induced neuronal cells degeneration in dopaminergic neuroblastoma SH-SY5Y cells. Hydrogen peroxide significantly reduced cell viability in SH-SY5Y cultured cells. An inhibitor of the enzyme that catalyzes the farnesylation of Ras proteins, FTI-277, and a competitive inhibitor of GTP-binding proteins, GDP-beta-S significantly decreased hydrogen peroxide-induced reduction in cell viability in SH-SY5Y cultured cells. The results of this study might indicate that a Ras-dependent signaling pathway plays a role in hydrogen peroxideinduced toxicity in neuronal cells.engMahidol UniversityHydrogen PeroxideToxicity InducesRas SignalingHuman NeuroblastomaSH-SY5YCultured CellsOpen Access articleResearch Article10.1155/2010/803815