Sanya SureramSarath P D SenadeeraPoonpilas HongmaneeChulabhorn MahidolSomsak RuchirawatPrasat KittakoopChulabhorn Research InstituteChulabhorn Graduate InstituteMahidol UniversitySouth Carolina Commission on Higher Education2018-06-112018-06-112012-04-15Bioorganic and Medicinal Chemistry Letters. Vol.22, No.8 (2012), 2902-2905146434050960894X2-s2.0-84859441948https://repository.li.mahidol.ac.th/handle/20.500.14594/13759Bisbenzylisoquinoline alkaloids, tiliacorinine (1), 2′- nortiliacorinine (2), and tiliacorine (3), isolated from the edible plant, Tiliacora triandra, as well as a synthetic derivative, 13′-bromo- tiliacorinine (4), were tested against 59 clinical isolates of multidrug-resistant Mycobacterium tuberculosis (MDR-MTB). The alkaloids 1-4 showed MIC values ranging from 0.7 to 6.2 μg/ml, but they exhibited the MIC value at 3.1 μg/ml against most MDR-MTB isolates. The present work suggests that bisbenzylisoquinoline alkaloids are potential new chemical scaffolds for antimycobacterial activity. © 2012 Elsevier Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.bmcl.2012.02.053