Ladawan SumunneeChaleena PimpasriMedena NoikhamSirilata YotphanMahidol University2019-08-232019-08-232018-01-01Organic and Biomolecular Chemistry. Vol.16, No.15 (2018), 2697-2704147705202-s2.0-85045841772https://repository.li.mahidol.ac.th/handle/20.500.14594/45274© The Royal Society of Chemistry. The persulfate-meditated oxidative C-N bond coupling of the C-H bond of quinoxalinones and the N-H bond of NH-sulfoximines is reported. The reaction proceeds smoothly under transition metal-free conditions and provides good to excellent yields of sulfoximidoyl-functionalized quinoxalinone products under mild conditions. The optimized conditions were found to be suitable for a range of sulfoximine and quinoxalinone substrates. This reaction offers a new and convenient strategy to directly install the sulfoximine moiety into the C3 position of quinoxalinone.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryArticleSCOPUS10.1039/c8ob00375k