Yongyuth YuthavongPintip RuenwongsaDhirayos WititsuwannakulSataporn Suttikulpitug2025-02-032025-02-03198920251989Thesis (M.Sc. (Biochemistry))--Mahidol University, 1989https://repository.li.mahidol.ac.th/handle/20.500.14594/103560Biochemistry (Mahidol University 1989)Study of folate uptake by P.falciparum infected red blood cells indicated that the increase in rated of uptake resulted form the intracellular parasites. Folate uptake was highest at the schizont stage and was icreased with percent parasitemia. The uptake was neither a carrier-mediated nor an active transport because it could not be competitively inhibited by folate analogues, was not dependent on cellular energy, and showed no saturation with folate concentration in the transporting medium. The data primarily suggested that the uptake was through pores formed during infection by the malarial parasite. From the present study the existence of a possible folate salvage pathway in P.falciparum could not be demonstrated.vii, 118 leaves : ill.application/pdfengผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้าErythrocytesInfectionPlasmodium FalciparumMaster ThesisMahidol University