W. WanachiwanawinS. VisudhiphanA. PinankijagumS. VatanavicharnMahidol University2018-08-102018-08-101993-12-01The Southeast Asian journal of tropical medicine and public health. Vol.24 Suppl 1, (1993), 71-75012515622-s2.0-0027903370https://repository.li.mahidol.ac.th/handle/20.500.14594/22627Results of different types of treatment in 416 adults with chronic idiopathic thrombocytopenic purpura (ITP) were analyzed. Of 368 patients treated with corticosteroids, 278 (77%) achieved complete response (CR ie, normalization of platelet count). However, only 18% of patients had continued complete response (CCR). Results of splenectomy was analyzed in 126 patients, 49% of them achieved CCR and 76% of them had beneficial effects from the operation. Emergency splenectomy was a life saving procedure in 8 of 11 patients with life-threatening hemorrhage. Vinca alkaloids gave a 50% transient CR. Immunosuppressive agents (cyclophosphamide, azathioprine) resulted in only 11% CCR.Mahidol UniversityMedicineArticleSCOPUS