Juthamas YosudjaiSopit WongkhamSiwanon JirawatnotaiWorasak KaewkongFaculty of Medicine, Khon Kaen UniversityNaresuan UniversityFaculty of Medicine, Siriraj Hospital, Mahidol University2020-01-272020-01-272019-01-01Biomedical Reports. Vol.10, No.3 (2019), 147-15520499442204994342-s2.0-85062662624https://repository.li.mahidol.ac.th/handle/20.500.14594/50396© 2019, Spandidos Publications. All rights reserved. Cholangiocarcinoma is a lethal biliary cancer, with an unclear molecular pathogenesis. Alternative splicing is a post‑transcriptional modification that generates mature mRNAs, which are subsequently translated into proteins. Aberrant alternative splicing has been reported to serve a role in tumor initiation, maintenance and metastasis in several types of human cancer, including cholangiocarcinoma. In this review, the aberrant splicing of genes and the functional contributions of the spliced genes, in the carcinogenesis, progression and aggressiveness of cholangiocarcinoma are summarized. In addition, factors that influence this aberrant splicing that may be relevant as therapeutic targets or prognosis markers for cholangiocarcinoma are discussed.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyReviewSCOPUS10.3892/br.2019.1188