Rungrot CherdtrakulkiatApilak WorachartcheewanSrisurang TantimavanichRatana LawungNujarin SinthupoomSupaluk PrachayasittikulSomsak RuchirawatVirapong PrachayasittikulChulabhorn Research InstituteMahidol UniversityMinistry of EducationChulabhorn Graduate Institute2020-03-262020-03-262020-02-01Drug Development Research. Vol.81, No.1 (2020), 127-13510982299027243912-s2.0-85074301327https://repository.li.mahidol.ac.th/handle/20.500.14594/53905© 2019 Wiley Periodicals, Inc. Methicillin-resistant Staphylococcus aureus (MRSA) infection has been considered to be one of global health problems due to limited classes of effective antimicrobial drugs. Herein, 8-hydroxyquinoline (8HQ) and its derivatives (1-7) were investigated for their anti-MRSA and antioxidant activities. Cloxyquin (2), a halogenated 8HQ, exerted the highest antimicrobial activity (MIC50 ≤ 5.57 μM) with high safety index, whereas an amino-derivative 7 showed the strongest antioxidant activity. Additionally, quantitative structure-activity relationship (QSAR) study demonstrated that mass, polarizability, topological charge, and van der Waals volume are essential properties governing the anti-MRSA activity. Taken together, cloxyquin was highlighted as a promising compound for further development as a novel anti-MRSA agent. QSAR findings would also benefit for further rational design of novel 8HQ-based compounds to combat the MRSA resistance.Mahidol UniversityPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1002/ddr.21611