Ratchanaporn ChokchaisiriNattawara ChaneiamSaovaros SvastiSuthat FucharoenJim VadolasApichart SuksamrarnRamkhamhaeng UniversityMahidol UniversityRoyal Children's Hospital, Melbourne2018-09-242018-09-242010-04-23Journal of Natural Products. Vol.73, No.4 (2010), 724-72815206025016338642-s2.0-77951613688https://repository.li.mahidol.ac.th/handle/20.500.14594/28733Three new labdane diterpenes, curcucomosins A-C (1-3), four known labdane diterpenes, 4-7, and a known diarylheptanoid, 8, were isolated from the aerial parts of Curcuma comosa. The structures of the new diterpenes were elucidated by spectroscopic data analysis. The fetal hemoglobin (Hb F) induction potency of the isolated compounds was examined using a K562 reporter cell line harboring the enhanced green fluorescence protein (EGFP) gene under the control of a Gγ-globin promoter. Compound 6, isocoronarin D, exhibited the highest Hb F induction effect of 1.6-fold at 20 μM. © 2010 The American Chemical Society and American Society of Pharmacognosy.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1021/np900568k