Ganopyrone A, a highly rearranged lanostane triterpenoid with antimalarial activity from artificially cultivated fruiting bodies of Ganoderma colossus

Chanphen R.Pruksatrakul T.Choowong W.Choeyklin R.Surawatanawong P.Isaka M.Mahidol University2024-06-062024-06-062024-08-01Phytochemistry Vol.224 (2024)00319422https://repository.li.mahidol.ac.th/handle/20.500.14594/98631Three previously undescribed highly modified lanostane triterpenoids, ganopyrone A, ganocolossusin I, and ganodermalactone Y, were isolated from the artificially cultivated fruiting bodies of the basidiomycete Ganoderma colossus TBRC-BCC 17711. Ganopyrone A possesses an unprecedented polycyclic carbon skeleton with an α-pyrone ring and C-18/C-23 bond. It showed antimalarial activity against Plasmodium falciparum K1 (multidrug-resistant strain) with an IC50 value of 7.8 μM (positive control: dihydroartemisinin, IC50 1.4 nM), while its cytotoxicity (Vero cells) was much weaker (IC50 103 μM).Biochemistry, Genetics and Molecular BiologyAgricultural and Biological SciencesGanopyrone A, a highly rearranged lanostane triterpenoid with antimalarial activity from artificially cultivated fruiting bodies of Ganoderma colossusArticleSCOPUS10.1016/j.phytochem.2024.1141682-s2.0-85194577698