Kunita PhakdeeyothinSirilata YotphanMahidol University2020-01-272020-01-272019-01-01Organic and Biomolecular Chemistry. Vol.17, No.26 (2019), 6432-6440147705202-s2.0-85068380881https://repository.li.mahidol.ac.th/handle/20.500.14594/50303© The Royal Society of Chemistry. A highly regioselective metal-free direct C-H thiolation of 2-pyridones with disulfides or thiols has been developed. A combination of persulfate and a commercially available halide source such as LiCl, NCS or I2 enables the successful direct incorporation of a sulfide moiety into the 5-position of pyridone under mild conditions, providing a useful and convenient approach for the preparation of a diverse array of 5-thio-substituted pyridones in moderate to excellent yields.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryArticleSCOPUS10.1039/c9ob01061k