Siwanon JirawatnotaiYiduo HuDavid M. LivingstonPiotr SicinskiHarvard Medical SchoolMahidol University2018-06-112018-06-112012-09-01Cancer Research. Vol.72, No.17 (2012), 4289-429315387445000854722-s2.0-84865710342https://repository.li.mahidol.ac.th/handle/20.500.14594/13625The human CCND1 gene, which encodes the cell-cycle protein cyclin D1, is one of the most frequently amplified genes in human cancers. Cyclin D1 activates the cyclin-dependent kinases CDK4 and CDK6 and drives cell proliferation. Beyond the cell-cycle role, the full repertoire of cyclin D1 functions in cancer cells is still unclear. Emerging evidence indicates that cyclin D1 may play a role in DNA damage response. In this review, we discuss observations linking cyclin D1 to DNA damage repair and summarize our recent findings, which show a cyclin D1 function in homologous recombination-mediated DNA repair. ©2012 AACR.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineReviewSCOPUS10.1158/0008-5472.CAN-11-3549