Chumpol AnamnartSiriwan PiyapittayananChulalongkorn UniversityFaculty of Medicine, Siriraj Hospital, Mahidol University2020-12-282020-12-282020-09-01Oxford Medical Case Reports. Vol.2020, No.9 (2020), 318-321205388552-s2.0-85096831867https://repository.li.mahidol.ac.th/handle/20.500.14594/60497© 2020 Oxford University Press. All rights reserved. The rare cheiro-oral-pedal syndrome (COPS) is characterized by sensory disturbances around the corner of the mouth, and in the hand and foot of the same side. The causative lesion is located in the thalamocortical projections, thalamus or brainstem and is usually due to ischemic or hemorrhagic stroke.We report a case of a patient with brain stem cavernous malformations presented as pure COPS with additional sensory disturbance in the thorax.We report this case to raise awareness of these very rare syndromes and demonstrate that mildly presenting symptoms can be caused by an underlying devastating condition.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS10.1093/omcr/omaa074