Alfredo GuarinoJuliet AguilarJames BerkleyIlse BroekaertRodrigo Vazquez-FriasLori HoltzAndrea Lo VecchioToufik MeskiniSean MooreJuan F. Rivera MedinaBhupinder SandhuAndrea SmarrazzoHania SzajewskaSuporn TreepongkarunaUniversity of the Philippines ManilaUniversidad Nacional Mayor de San MarcosMedical University of WarsawWellcome Trust Research Laboratories NairobiUniversity of OxfordWashington University School of Medicine in St. LouisUniversity of VirginiaMohammed V University in RabatUniversità degli Studi di Napoli Federico IIFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityBristol Royal Hospital for ChildrenUniklinik KölnHospital Infantil de Mexico Federico Gomez2020-06-022020-06-022020-05-01Journal of pediatric gastroenterology and nutrition. Vol.70, No.5 (2020), 694-701153648012-s2.0-85084104255https://repository.li.mahidol.ac.th/handle/20.500.14594/56248The incidence of gastroenteritis has greatly reduced due to improved hygiene conditions in developing countries and the use of rotavirus vaccine. Still thousands of children, however, die from gastroenteritis, most of them in poor countries. Yet gastroenteritis management is simple, inexpensive, and effective and is largely the same all over the world. Universal guidelines for gastroenteritis guide the management and include simple interventions put forward early in the course of the disease. Treatment includes rehydration, continuing oral feeding, and anti-infective drugs in selected clinical conditions related to the symptoms or to host-related risk, and possible additional drug treatment to reduce the duration and severity of symptoms. There may be minor geographical differences in the treatment applied due to health care organizations that do not substantially change the standard universal recommendations. Prevention is recommended with sanitation interventions and rotavirus universal immunization. Implementation of those interventions through educational initiatives and local programs in target areas are needed. A series of recommendations for interventions, education, and research priorities are included here with the aim of reducing the burden of gastroenteritis, to be pursued by scientists, physicians, policy makers, and stakeholders involved. They include the need of recommendations for the management of gastroenteritis in malnourished children, in those with chronic conditions, in neonates, and in emergency settings. A reference system to score dehydration, the definition of optimal composition of rehydration solution and the indications for anti-infective therapy are also included. Rotavirus immunization should be actively promoted, and evidence-based guidelines should be universally implemented. Research priorities are also indicated.Mahidol UniversityMedicineArticleSCOPUS10.1097/MPG.0000000000002669