Cytotoxic ent-abietane diterpenoids, banyangmbolides A-E, from the leaves of Suregada occidentalis

Olaranont Y.Mas-Claret E.Cheek M.Prescott T.A.K.Onana J.M.Langat M.K.Mahidol University2024-02-192024-02-192024-02-15Heliyon Vol.10 No.3 (2024)24058440https://repository.li.mahidol.ac.th/handle/20.500.14594/97256The chemical investigation of a leaf extract from a herbarium specimen of Suregada occidentalis collected in Banyang Mbo Wildlife Sanctuary, Southwest Region, Cameroon, yielded five undescribed ent-abietane diterpenoids, banyangmbolides A-E, (1–5), and four known diterpenoids, gelomulides A (6), B (7), D (8) and O (9). The structures of the isolated compounds were determined using NMR, IR, ECD and HRESIMS. Compounds 5, 7 and 8, showed 48–55% inhibition at 200 μM against FM-55-M1 human melanoma cells.MultidisciplinaryCytotoxic ent-abietane diterpenoids, banyangmbolides A-E, from the leaves of Suregada occidentalisArticleSCOPUS10.1016/j.heliyon.2024.e259172-s2.0-85184774488