The inhibitory effect of capsaicin on intestinal glucose absorption in vitro. II. Effect of capsaicin upon intestinal Na+-K+-ATPase activities

Yongyot monsereenusornThirayudth GlinsukonMahidol University2018-06-012018-06-011979-01-01Toxicology Letters. Vol.4, No.5 (1979), 399-406037842742-s2.0-0018699755https://repository.li.mahidol.ac.th/handle/20.500.14594/1328314.0 mg/100 ml capsaicin, incubated in everted sac preparations, produced no significant inhibition of intestinal Na + -K + -ATPase in the rat, but a 22.60% inhibition in the hamster. This differential effect was substantiated by in vitro studies of aliquots of crude mucosal homogenate. the ID 50 s for rat and hamster being 35.0 and 12.0 mg/100 ml, respectively. Capsaicin-induced-inhibition of intestinal glucose transport may be due in part to a secondary inhibitory effect on the ATPase dependent sodium pump. © 1979.Mahidol UniversityPharmacology, Toxicology and PharmaceuticsThe inhibitory effect of capsaicin on intestinal glucose absorption in vitro. II. Effect of capsaicin upon intestinal Na+-K+-ATPase activitiesArticleSCOPUS10.1016/0378-4274(79)90052-3