Nicholas J. WhiteElizabeth A. AshleyJudith RechtMichael J. DelvesAndrea RueckerFrank M. SmithuisAlice C. EziefulaTeun BousemaChris DrakeleyKesinee ChotivanichMallika ImwongSasithon PukrittayakameeJetsumon PrachumsriCindy ChuChiara AndolinaGermana BanconeTran T. HienMayfong MayxayWalter R.J. TaylorLorenz Von SeidleinRic N. PriceKaren I. BarnesAbdoulaye DjimdéFeiko Ter KuileRoly GoslingIngrid ChenMehul J. DhordaKasia StepniewskaPhilippe GuérinCharles J. WoodrowArjen M. DondorpNicholas P.J. DayFrancois H. NostenMahidol UniversityNuffield Department of Clinical MedicineImperial College LondonMyanmar Oxford Clinical Research UnitLondon School of Hygiene & Tropical MedicineUCLMahosot HospitalMenzies School of Health ResearchUniversity of Cape TownUniversity of Bamako Faculty of Medicine, Pharmacy and Odonto-StomatologyLiverpool School of Tropical MedicineUCSF Global Health SciencesChurchill Hospital2018-11-092018-11-092014-12-09Malaria Journal. Vol.13, No.1 (2014)147528752-s2.0-84926450796https://repository.li.mahidol.ac.th/handle/20.500.14594/33942© 2014 White et al. Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in falciparum malaria include measurement of the duration of gametocytaemia, the rate of gametocyte clearance or the area under the gametocytaemia-time curve (AUC). These may provide useful comparative information, but they underestimate dose-response relationships for transmission-blocking activity. Following 8-aminoquinoline administration P. falciparum gametocytes are sterilized within hours, whereas clearance from blood takes days. Gametocytaemia AUC and clearance times are determined predominantly by the more numerous female gametocytes, which are generally less drug sensitive than the minority male gametocytes, whereas transmission-blocking activity and thus infectivity is determined by the more sensitive male forms. In choosing doses of transmission-blocking drugs there is no substitute yet for mosquito-feeding studies.Mahidol UniversityImmunology and MicrobiologyMedicineReviewSCOPUS10.1186/1475-2875-13-483