Maneekarn ChinworrungseePrasat KittakoopMasahiko IsakaPacharee MaithipSumalee SupothinaYodhathai ThebtaranonthMahidol UniversityThailand National Center for Genetic Engineering and Biotechnology2018-07-242018-07-242004-04-01Journal of Natural Products. Vol.67, No.4 (2004), 689-692016338642-s2.0-2042517594https://repository.li.mahidol.ac.th/handle/20.500.14594/21208An antimalarial macrocyclic polylactone, menisporopsin A (1), was isolated from a cell extract of the seed fungus Menisporopsis theobromae. The structure of 1 was elucidated on the basis of spectroscopic analysis and chemical transformations, with the absolute configuration established by application of the modified Mosher method and by using chiral HPLC. Menisporopsin A (1) possesses an unprecedented residue, 2,4-dihydroxy-6-(2,4-dihydroxy-n-pentyl)benzoic acid. This compound exhibited antimalarial activity, with an IC50 value of 4.0 μg mL -1, and antimycobacterial activity (MIC value of 50 μg mL -1).Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1021/np0304870