Hassa N.Punnita S.Uppalabat T.La-ongthong K.Sawektreeratana N.Janthakit P.Nalaoh P.Promarak V.Leowanawat P.Soorukram D.Reutrakul V.Katrun P.Bunchuay T.Kuhakarn C.Mahidol University2025-10-202025-10-202025-10-10Journal of Organic Chemistry Vol.90 No.40 (2025) , 14057-1406500223263https://repository.li.mahidol.ac.th/handle/123456789/112671Described herein is an efficient and novel method for the synthesis of 6-arylindolo[1,2-a]quinoline-5,7-diones from 1-(2-ethynylphenyl)-1H-indoles. The reaction readily proceeded via a tandem process, leading to the desired products in moderate yields. The reaction can accommodate a broad range of functional groups and is efficient on a gram-scale synthesis. Under standard reaction conditions, 4-phenylpyrrolo[1,2-a]quinoline-3,5-dione can be readily accessed by using 1-(2-(phenylethynyl)phenyl)-1H-pyrrole as a substrate. The single-crystal X-ray diffraction data confirm the chemical structure of the product. Photophysical properties of some selected 6-arylindolo[1,2-a]quinoline-5,7-diones were studied by UV–visible and fluorescence spectroscopy.ChemistryArticleSCOPUS10.1021/acs.joc.5c012022-s2.0-10501845662915206904