Masahiko IsakaChotika SuyarnsestakornMorakot TanticharoenPalangpon KongsaereeYodhathai ThebtaranonthThailand National Center for Genetic Engineering and BiotechnologyMahidol University2018-07-242018-07-242002-03-08Journal of Organic Chemistry. Vol.67, No.5 (2002), 1561-1566002232632-s2.0-0037040681https://repository.li.mahidol.ac.th/handle/20.500.14594/20136Aigialomycins A-E (2-6), new 14-membered resorcylic macrolides, were isolated together with a known hypothemycin (1) from the mangrove fungus, Aigialus parvus BCC 5311. Structures of these compounds, including absolute configuration, were elucidated by spectroscopic methods, chemical conversions, and X-ray crystallographic analysis. Hypothemycin and aigialomycin D (5) exhibited in vitro antimalarial activity with IC50 values of 2.2 and 6.6 μg/mL, respectively, while other analogues were inactive. Cytotoxicities of these compounds were also evaluated.Mahidol UniversityChemistryArticleSCOPUS10.1021/jo010930g