Varitta TanawootPornpun VivithanapornTanapan SiangchamKrai MeemonNakorn NiamnontPrasert SobhonMontakan TamtinKant SangpairojFaculty of Medicine Ramathibodi Hospital, Mahidol UniversityFaculty of Medicine, Thammasat UniversityMahidol UniversityBurapha UniversityKing Mongkut's University of Technology ThonburiPhetcha Buri Coastal Aquaculture Research and Development Center2022-08-042022-08-042021-04-01Science and Technology Asia. Vol.26, No.2 (2021), 128-137258690272-s2.0-85109861701https://repository.li.mahidol.ac.th/handle/20.500.14594/75687Glioblastoma is one the most aggressive types of brain cancers resistant to conventional anti-neoplastic drugs. Marine seaweeds possess valuable bioactive compounds for disease prevention and therapy, including for a number of cancers. Caulerpa lentillifera is a tropical marine seaweed containing various minerals and bioactive ingredients. This study demonstrated the activity of C. lentillifera hexane extract (CLHE) against A172 human glioblastoma cells. The extract exerted growth-inhibitory effects by inhibiting cell proliferation and inducing apoptosis. CLHE also induced ROS accumulation and altered mitochondrial membrane potential in A172 cells. Taken together, CLHE might be a potential anticancer agent for use against glioblastoma.Mahidol UniversityAgricultural and Biological SciencesMathematicsMultidisciplinaryArticleSCOPUS