Benjamas ChuaychooRungsunn TungtrongchitrWantanee KriengsinyosSiriporn TuntipopipatNattira On-NomChaowanee ChupeerachMahidol UniversityFaculty of Medicine, Siriraj Hospital, Mahidol University2019-08-232019-08-232018-09-01Personalized Medicine. Vol.15, No.5 (2018), 371-3791744828X174105412-s2.0-85054626575https://repository.li.mahidol.ac.th/handle/20.500.14594/45055© 2018 Future Medicine Ltd. Aim: The risk of vitamin D binding protein (DBP) variations in chronic obstructive pulmonary disease (COPD) compared with non-COPD Thai males were investigated. Materials & methods: The rs7041 and rs4588 polymorphisms of the DBP gene and protein level were measured in 136 COPD and 68 non-COPD Thai males. Results: In the COPD group, GC1-1 gave increased forced expiratory volume at 1 s % predicted compared with GC1-2 but with no significant difference. Significantly lower average DBP serum levels were observed in COPD than non-COPD subjects. Positive correlation between serum DBP and forced expiratory volume at 1 s % predicted was observed in non-COPD subjects. Discussion & conclusion: DBP variations might be associated with risk factors in COPD caused by both inflammatory and vitamin D circulation processes.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.2217/pme-2018-0005