Chaiyong NualyongVarat WoranisarakulNgoentra TantranontEkkarin ChotikawanichSantosh ShresthaTawatchai TaweemonkongsapFaculty of Medicine, Siriraj Hospital, Mahidol UniversityPokhara Academy of Health Sciences2019-08-282019-08-282018-05-01Siriraj Medical Journal. Vol.70, No.3 (2018), 254-259222880822-s2.0-85051598423https://repository.li.mahidol.ac.th/handle/20.500.14594/46708© 2018, Faculty of Medicine Siriraj Hospital, Mahidol University. Objective: Metastatic malignant melanoma of the urinary bladder is extremely rare in clinical practice, herein, we review literature to demonstrate epidemiology, management and prognosis of this rare condition. Case presentation: A 57-year-old male with history of malignant melanoma of left big toe was referred to the urology division with the complaint of intermittent painless gross hematuria. Cystoscopy revealed multiple bladder masses, hence transurethral resection of bladder tumor was performed. Histologic and immunohistochemical examination revealed metastatic malignant melanoma involving urinary bladder mucosa. Conclusion: Suspicion of metastasis should be raised in a patient with urinary symptom, especially if the history of malignant melanoma is present. Cystoscopy and biopsy is recommended if metastatic disease is suspected. While long-term survival is poor, management should be individualized according to the patient's conditions, symptoms and severity of disease.Mahidol UniversityMedicineArticleSCOPUS10.14456/smj.2018.41