Monpat ChamnanphonAndrea GaedigkNatchaya VanwongNopphadol NuntamoolYaowaluck HongkaewApichaya PuangpetchChonlaphat SukasemChulalongkorn UniversityFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityUniversity of Missouri-Kansas CityPayap University2019-08-232019-08-232018-01-01Pharmacogenomics. Vol.19, No.12 (2018), 947-96017448042146224162-s2.0-85051119071https://repository.li.mahidol.ac.th/handle/20.500.14594/45326© 2018 Future Medicine Ltd. The highly polymorphic CYP2D6 gene locus leads to a wide range of enzyme activity. Since there are limited data for Thai, the major aim was to investigate CYP2D6 genetic variation in a large Thai population (n = 920). CYP2D6 genotyping was performed using four different platforms. Genotype call rates of the Luminex xTAG® and AmpliChip CYP450 test were 96.5% and 87.4%, respectively. Based on Luminex xTAG® data, the most common alleles and genotypes were ∗1 0 (49.6%), ∗1 (24.6%), ∗2 (10.8%), ∗5 (6.7%), ∗41 (6.5%) and ∗1/∗10 (23.9%), ∗10/∗10 (21.5%), ∗2/∗10 (9.4%), ∗5/∗10 (6.9%), ∗10/∗41 (5.7%), respectively. Challenges and limitations of the platforms evaluated are discussed. These data add to our knowledge regarding interethnic variability in CYP2D6 activity and contribute to improving drug therapy in the Thai.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.2217/pgs-2018-0075