Norito KanedaJohn M. PezzutoD. Doel SoejartoA. Douglas KinghornNorman R. FarnsworthThawatchai SantisukPatoomratana TuchindaJinda UdchachonVichai ReutrakulUniversity of Illinois at ChicagoThailand Royal Forest DepartmentMahidol University2018-08-102018-08-101991-01-01Journal of Natural Products. Vol.54, No.1 (1991), 196-20615206025016338642-s2.0-0026083261https://repository.li.mahidol.ac.th/handle/20.500.14594/22012From a cytotoxic Et2O soluble extract of Muntingia calabura roots, twelve new flavonoids were isolated, constituting seven flavans 1–7, three flavones 8, 10, and 12, and two biflavans 9 and 11. The structures of compounds 1–12 were established by the interpretation of spectral data, with the nmr assignments of these constituents being based on1H−1H COSY,1H−13C HETCOR, and selective INEPT experiments. This is the first report of the occurrence of 7,8-di-O-substituted flavans, biflavans, and flavones. Most of the isolates demonstrated cytotoxic activity when tested against cultured P-388 cells, with the flavans being more active than the flavones. Furthermore, certain of these structurally related flavonoids exhibited somewhat selective activities when evaluated with a number of human cancer cell lines. © 1991, American Chemical Society. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1021/np50073a019