Pattana SornmayuraPaisan BoonsakanAbhasnee SobhonslidsukSuthus SriphojanartChakrapan EuanorasetrSukhum BunyaratvejMahidol UniversityFaculty of Medicine, Ramathibodi Hospital, Mahidol University2018-08-242018-08-242007-02-01Journal of the Medical Association of Thailand. Vol.90, No.2 (2007), 352-36201252208012522082-s2.0-33847692754https://repository.li.mahidol.ac.th/handle/20.500.14594/24987Objective: Detect the early histological changes relating to human hepatocarcinogenesis in three nodular hepatocellular lesions Material and Method: Three cases of dysplastic nodules and one of small hepatocellular carcinoma were obtained from the authors' surgical-pathology file during 2000-2005 for a histopathological study in relevance to the early changes during hepatocarcinogenesis by employing hematoxylin and eosin stain, as well as some immunohistochemical staining. Results: One nodular hepatocellular lesion, diagnosed as a complex lesion of focal nodular hyperplasia contained a microscopic focus (1.5 mm in diameter) of combined hepatocellular and cholangiocarcinoma. Conclusion: The small dysplastic hepatocytes subjected to neoplastic transformation combined hepatocellular and cholangiocarcinoma and are the precursorial cells of hepatocellular carcinoma. Chronic viral hepatitis B or C, aflatoxin B1 and nitrosamine(s), as well as some nodular hepatocellular lesions share distinct roles in the complex process of hepatocarcinogenesis pertaining to this Southeast Asian country.Mahidol UniversityMedicineArticleSCOPUS