Wilai ThanasarnaksornVorapot SiramangkhalanonDiane Irvine DuncanInna BelenkyPoudre Valley HospitalFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityDoctor Younger ClinicViora Inc.Private Practice2019-08-282019-08-282018-04-01Journal of Cosmetic Dermatology. Vol.17, No.2 (2018), 184-19214732165147321302-s2.0-85044350498https://repository.li.mahidol.ac.th/handle/20.500.14594/46799© 2017 Wiley Periodicals, Inc. Background: Fractional radiofrequency (RF) technology is often the preferable skin resurfacing treatment, especially among Asian patients. Second generation fractional RF technology has exclusive capability to produce separate biological responses (ablation, coagulation, or a combination of both) with 3 distinguished penetration depth programs. Aims: The aim of this study was to evaluate the efficacy and safety of a fractional RF handpiece such as this, on the Thai population. Methods: Fifty-five Thai patients were treated with a fractional RF handpiece. The clinical assessment included a pain score, satisfaction survey, physician assessment, a combined patient and physician's assessment of skin condition, and clinical photographic assessments. The wound healing response was evaluated according to 5-time points: immediately after applying a pulse, post 24 hours, post 7 days, post 1 month and post 8 weeks. Results: The obtained patient satisfaction score was “very satisfied” among 74% of the patients, post 3 sessions. Positive correlation was found between patient satisfaction and the physician's assessment. The skin condition assessment showed an increase from an average of 4.2 to 7.9. All treated symptoms improved after each treatment and the clinical outcome lasted at least up to 3–5 months. No significant adverse events were recorded. The in vivo prospective study showed a dose-related response in the deepness of the coagulation injury. In addition, there was evidence for a progressive healing process beginning shortly after exposure and completed within a week. Conclusions: This study clinically and histologically supports the efficacy of fractional RF handpiece in question with a high safety profile.Mahidol UniversityMedicineArticleSCOPUS10.1111/jocd.12413