Jean Charles FruchartRaul D. SantosCarlos Aguilar-SalinasMasanori AikawaKhalid Al RasadiPierre AmarencoPhilip J. BarterRichard CeskaAlberto CorsiniJean Pierre DesprésPatrick DuriezRobert H. EckelMarat V. EzhovMichel FarnierHenry N. GinsbergMichel P. HermansShun IshibashiFredrik KarpeTatsuhiko KodamaWolfgang KoenigMichel KrempfSoo LimAlberto J. LorenzattiRuth McPhersonJesus Millan Nuñez-CortesBørge G. NordestgaardHisao OgawaChris J. PackardJorge PlutzkyCarlos I. Ponte-NegrettiAruna PradhanKausik K. RayZeljko ReinerPaul M. RidkerMassimiliano RuscicaShaukat SadikotHitoshi ShimanoPiyamitr SritaraJane K. StockTa Chen SuAndrey V. SusekovAndré TartarMarja Riitta TaskinenAlexander TenenbaumLale S. TokgözoǧluBrian TomlinsonAnne Tybjærg-HansenPaul ValensiMichal VrablíkWalter WahliGerald F. WattsShizuya YamashitaKoutaro YokoteAlberto ZambonPeter LibbyINRA Pays de la LoireHospital y CRS El PinoJichi Medical UniversitySeoul National University Bundang HospitalSultan Qaboos University HospitalNational Medical Research Center of Cardiology, MoscowHospital General Universitario Gregorio MarañonUniversité LavalUniversity of Western AustraliaKøbenhavns UniversitetCentre Hospitalier Universitaire de DijonUniversità degli Studi di MilanoJaslok Hospital and Research CentreUniversity of Helsinki Faculty of MedicineUniversity of New South Wales (UNSW) AustraliaUniversidad Complutense de MadridUniversity of OxfordHôtel Dieu CHU de NantesUniversity of TokyoOsaka UniversityHacettepe ÜniversitesiInstituto do Coracao do Hospital das ClinicasBrigham and Women's HospitalCharles UniversityFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityImperial College LondonAmtssygehuset i GentofteUniversity of TsukubaCliniques Universitaires Saint-LucChaim Sheba Medical Center IsraelUniversity of Ottawa Heart InstituteVagelos College of Physicians and SurgeonsUniversität UlmUniversity of Colorado Health Sciences CenterUniversite Paris 13Instituto Nacional de la Nutrición Salvador ZubiranDeutsches Herzzentrum MünchenRigshospitaletUniversity of Zagreb School of MedicineUniversite Paris 7- Denis DiderotNanyang Technological UniversityNational Taiwan UniversityTel Aviv University, Sackler Faculty of MedicineBoston Medical CenterHopital G. et R. Laennec CHU de NantesChinese University of Hong KongChiba UniversityHarvard Medical SchoolUniversity of GlasgowEscuela de Medicina y Ciencias de la Salud TecSaludINRA Occitanie-ToulouseUniversità degli Studi di PadovaUniversité Lille 2 Droit et SantéUniversité de Lausanne (UNIL)R3i FoundationDAMIC Medical Institute/Rusculleda Foundation for ResearchRussian Medical Academy for Postgraduate EducationNational Cerebral and Cardiovascular CenterCORDOBARinku General Medical Center2020-01-272020-01-272019-06-04Cardiovascular Diabetology. Vol.18, No.1 (2019)147528402-s2.0-85066822428https://repository.li.mahidol.ac.th/handle/20.500.14594/51595© 2019 The Author(s). In the era of precision medicine, treatments that target specific modifiable characteristics of high-risk patients have the potential to lower further the residual risk of atherosclerotic cardiovascular events. Correction of atherogenic dyslipidemia, however, remains a major unmet clinical need. Elevated plasma triglycerides, with or without low levels of high-density lipoprotein cholesterol (HDL-C), offer a key modifiable component of this common dyslipidemia, especially in insulin resistant conditions such as type 2 diabetes mellitus. The development of selective peroxisome proliferator-activated receptor alpha modulators (SPPARMα) offers an approach to address this treatment gap. This Joint Consensus Panel appraised evidence for the first SPPARMα agonist and concluded that this agent represents a novel therapeutic class, distinct from fibrates, based on pharmacological activity, and, importantly, a safe hepatic and renal profile. The ongoing PROMINENT cardiovascular outcomes trial is testing in 10,000 patients with type 2 diabetes mellitus, elevated triglycerides, and low levels of HDL-C whether treatment with this SPPARMα agonist safely reduces residual cardiovascular risk.Mahidol UniversityMedicineReviewSCOPUS10.1186/s12933-019-0864-7