Chulanetra M.Mahidol University2023-11-212023-11-212023-01-01Current Clinical Microbiology Reports (2023)https://repository.li.mahidol.ac.th/handle/20.500.14594/91113Purpose of Review: The success and failure of therapeutic antibodies against SARS-CoV-2 offer a lesson on therapeutic antibody design and development. Recent Findings: Therapeutic antibody against SARS-CoV-2 facing challenging antibody escape mutation. A paratope design strategy targeting pancoronavirus conserved epitope(s) and combining two antibodies as antibody cocktails or bispecific antibodies may overcome antibody escape mutations of the SARS-CoV-2 spike. Instead of designing broadly neutralizing antibodies, repurposing antibodies can target viral or host molecules to inhibit the virus and alleviate dysregulation of the host immune response. Summary: Detailed strategies for engineering therapeutic antibodies, including antibody format, are reviewed in this article.MedicineReviewSCOPUS10.1007/s40588-023-00212-72-s2.0-8517647198021965471