A. PanthongD. KanjanapothiP. TuntiwachwuttikulO. PancharoenV. ReutrakulChiang Mai UniversitySilpakorn UniversityThailand Ministry of Public HealthMahidol University2018-02-272018-02-271994-01-01Phytomedicine. Vol.1, No.2 (1994), 141-144094471132-s2.0-85016784652https://repository.li.mahidol.ac.th/handle/20.500.14594/9540Fourteen flavonoids (flavones,- flavanones and chalcones) were assayed for oral antiinflammatory activity using carrageenan-induced hind paw edema in rats. The structural features necessary for antiinflammatory activity appear to be the presence of methoxyl groups at C5 and C7 of ring A and the pyrano ring B of the flavonoid molecule. Negligible or low antiinflammatory activities were found in the chalcone derivatives. The difference in the efficacy of the flavonoids tested possibly depends on their pharmacokinetic properties. © 1994, Gustav Fischer Verlag, Stuttgart · Jena · New York. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/S0944-7113(11)80032-2