Gahatraj J.Visudtibhan P.J.Junda T.Butsing N.Mahidol University2023-12-202023-12-202024-01-01Journal of Health Research Vol.38 (2024) , 146-15308574421https://repository.li.mahidol.ac.th/handle/20.500.14594/91573Background: End-stage renal disease (ESRD) puts tremendous burdens upon affected patients and their support persons in Nepal. The health-related quality of life (HRQoL) among Nepalese persons with hemodialysis-dependent ESRD is not well understood. This study aimed to examine HRQoL and its predicting factors among persons undergoing hemodialysis in Nepal. Methods: A purposive sampling was applied to recruit 106 persons with ESRD receiving hemodialysis at a tertiary hospital in Nepal between October and December 2021. The structured questionnaires included personal information, the World Health Organization Quality of Life instruments (WHOQOL-BREF), the fatigue assessment scale (FAS), the Hamilton depression rating scale (HDRS), and the social support scale (SSS). Data was collected through interviews. Descriptive statistics and multiple regression analysis were used to analyze data. Results: The mean age of participants was 47.3 years, and 52.8% were female. The mean score of overall HRQoL was 59.8. Predictors of overall HRQoL included depression, medical payment, marital status, age, social support, and hemodialysis complications (p < 0.05) with an explained variance of 43.2%. Predictors of physical health included age, medical payment, and depression. Significant predictors of psychological health included depression, hematocrit level, age, marital status, social support, and hemodialysis complications. Social relationships were predicted by depression, marital status, hemodialysis complications, and diabetes mellitus. Environment domain was significantly predicted by depression. Conclusions: Nurses should focus on assessing HRQoL and its significant factors in ESRD persons receiving hemodialysis. An early diagnosis of depression and proper management could improve quality of life of persons undergoing hemodialysis.MedicineArticleSCOPUS10.56808/2586-940X.10702-s2.0-851794726362586940X