Vilailak PrachyawarakornChulabhorn MahidolSanya SureramSuwannee SangpetsiripanSuthep WiyakruttaSomsak RuchirawatPrasat KittakoopChulabhorn Research InstituteChulabhorn Graduate InstituteMahidol UniversityThe Institute of Science and Technology for Research and Development, Mahidol University2018-07-122018-07-122008-01-01Planta Medica. Vol.74, No.1 (2008), 69-72003209432-s2.0-39149083695https://repository.li.mahidol.ac.th/handle/20.500.14594/19010Five metabolites, (Z)-6-benzylidene-3-hydroxymethyl-1,4-dimethyl-3- methylsulfanylpiperazine-2,5-dione (1), (3S,3′R)-3-(3′-hydroxybutyl) -7-methoxyphthalide (2), (S)-3-butyl-7-methoxyphthalide (3), (3R,6R)-bisdethiodi(methylthio)-hyalodendrin (4), and bis-N-norgliovictin (5), were isolated from the culture broth of the marine derived fungus of the order Pleosporales strain CRIF2. Compounds 1 and 2 are new fungal metabolites, while 3 was isolated for the first time as a natural product. Compounds 1,3, and 4 exhibited only weak cytotoxic activity, while 5 was inactive at 50 μg/mL. © Georg Thieme Verlag KG Stuttgart.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1055/s-2007-993783