On Ying YuenMueangkaew CharoensakChau Ming SoChutima KuhakarnFuk Yee KwongHong Kong Polytechnic UniversityMahidol University2018-11-232018-11-232015-01-01Chemistry - An Asian Journal. Vol.10, No.4 (2015), 857-8611861471X186147282-s2.0-84925384804https://repository.li.mahidol.ac.th/handle/20.500.14594/35774© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The first general examples of direct coupling of heteroaryl chlorides, especially substituted 2-pyridyl chlorides which were previously found to be problematic, with electron-deficient polyfluoroarenes are reported. Pd(OAc)2associated with 3-(dicyclohexylphosphino)-2-phenylindole L1 serves as the effective catalyst which allows the challenging direct coupling of heteroaryl chlorides and polyfluoroarenes. In addition to heterocycles, a wide range of non-activated and activated aryl chlorides and alkenyl chlorides were also applicable under this catalyst system. A catalyst loading down to 1 mol% Pd can be achieved.Mahidol UniversityChemistryArticleSCOPUS10.1002/asia.201500048