Sujittra DeesamerUdom KokpolWarinthorn ChavasiriSoazig DouillardVincent PeyrotNicolas VidalSebastien CombesJean Pierre FinetMahidol UniversityAix Marseille Universite2018-08-242018-08-242007-12-24Tetrahedron. Vol.63, No.52 (2007), 12986-12993004040202-s2.0-36148973932https://repository.li.mahidol.ac.th/handle/20.500.14594/24057Mucronulatol 1 and violanone 2 isolated from Dalbergia oliveri Gamble, and the corresponding isoflavone 3 were prepared by ligand coupling reactions involving organolead reagent. Biological studies have shown a significant cytotoxic effect against an HBL100 leukemia cell line only for isoflavan 1 with an IC50value amounting to 5.7 μM. All the drugs modestly inhibit the in vitro microtubule assembly, independently of the cytotoxic ability. Natural compounds 1 and 2 have no antibacterial activity, but are potent inhibitors of the Fusarium oxysporum phytopathogenic fungal growth. © 2007 Elsevier Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.tet.2007.10.030