Pharmacokinetics of oral doxycycline during combination treatment of severe falciparum malaria

Paul N. NewtonJean François ChauletAlan BrockmanWirongrong ChierakulArjen DondorpRonatrai RuangveerayuthSornchai LooareesuwanCyril MounierNicholas J. WhiteShoklo Malaria Research UnitMae Sot General HospitalMahidol UniversityChurchill HospitalHopital Debrousse2018-06-212018-06-212005-04-01Antimicrobial Agents and Chemotherapy. Vol.49, No.4 (2005), 1622-1625006648042-s2.0-16244414614https://repository.li.mahidol.ac.th/handle/20.500.14594/17022The pharmacokinetics of oral doxycycline administered at 200 mg every 24 h were investigated in 17 patients recovering from severe Plasmodium falciparum malaria. The data suggest that the doses of doxycycline currently recommended (circa 3.5 mg/kg of body weight daily) may not be optimal. Copyright © 2005, American Society for Microbiology. All Rights Reserved.Mahidol UniversityMedicinePharmacology, Toxicology and PharmaceuticsPharmacokinetics of oral doxycycline during combination treatment of severe falciparum malariaArticleSCOPUS10.1128/AAC.49.4.1622-1625.2005