Chen L.K.Hsiao F.Y.Akishita M.Assantachai P.Lee W.J.Lim W.S.Muangpaisan W.Kim M.Merchant R.A.Peng L.N.Tan M.P.Won C.W.Yamada M.Woo J.Arai H.Mahidol University2025-11-192025-11-192025-01-01Nature Aging (2025)https://repository.li.mahidol.ac.th/handle/123456789/113118The Asian Working Group for Sarcopenia (AWGS) presents an updated 2025 consensus reframing sarcopenia management through a life-course approach to muscle health promotion. While aligning with the Global Leadership Initiative in Sarcopenia (GLIS), this update provides healthcare providers with Asia-specific guidance. The consensus introduces three key refinements: first, expanding sarcopenia diagnosis to middle-aged adults (50‒64 years) with validated diagnostic thresholds; second, simplifying the diagnostic algorithm to require only concurrent low muscle mass and strength, with physical performance as an outcome measure; and third, introducing an enhanced muscle health framework recognizing skeletal muscle as vital for healthy longevity, emphasizing cross-talk with brain, bone, adipose tissue and immune systems. This framework leverages the World Health Organization’s Integrated Care for Older People (ICOPE) implementation for enhanced case-finding through natural overlap between muscle health and ICOPE’s intrinsic capacity domains. The consensus provides evidence-based recommendations for multimodal interventions that combine resistance exercise with nutritional supplementation, representing advancement toward proactive muscle health promotion and establishing a framework for reducing age-related decline in Asian populations.NeuroscienceBiochemistry, Genetics and Molecular BiologyMedicineReviewSCOPUS10.1038/s43587-025-01004-y2-s2.0-10502123874826628465