Massimo SartelliFikri M. Abu-ZidanFausto CatenaEwen A. GriffithsSalomone Di SaverioRaul CoimbraCarlos A. OrdoñezAri LeppaniemiGustavo P. FragaFederico CoccoliniFerdinando AgrestaAsrhaf AbbasSaleh Abdel KaderJohn AgboolaAdamu AmhedAdesina AjibadeSeckin AkkucukBandar AlharthiDimitrios AnyfantakisGoran AugustinGianluca BaiocchiMiklosh BalaOussama BaraketSavas BayrakGiovanni BellanovaMarcelo A. BeltrànRoberto BiniMatthew BoalAndrey V. BorodachKonstantinos BouliarisFrederic BrangerDaniele BrunelliMarco CataniAsri Che JusohAlain Chichom-MefireGianfranco CocorulloElif ColakDavid CostaSilvia CostaYunfeng CuiGeanina Loredana CurcaTerry CurryKoray DasSamir DelibegovicZaza DemetrashviliIsidoro Di CarloNadezda DrozdovaTamer El ZalabanyMushira Abdulaziz EnaniMario FaroMahir GachabayovTeresa Giménez MaurelGeorgios GkiokasCarlos Augusto GomesRicardo Alessandro Teixeira GonsagaGianluca GuercioniAli GunerSanjay GuptaSandra GutierrezMartin HutanOrestis IoannidisArda IsikYoshimitsu IzawaSumita A. JainMantas JokubauskasAleksandar KaramarkovicSaila KauhanenRobin KaushikJakub KenigVladimir KhokhaJae Il KimVictor KongRenol KoshyAvidyl KrasniqiAshok KshirsagarZygimantas KuliesiusKonstantinos LasithiotakisPedro LeãoJae Gil LeeMiguel LeonAintzane Lizarazu PérezVarut LohsiriwatEudaldo López-Tomassetti FernandezEftychios LostoridisRaghuveer MnPiotr MajorAthanasios MarinisDaniele MarrelliAleix Martinez-PerezSanjay MarwahMichael McFarlaneRenato Bessa MeloCristian MesinaNick MichalopoulosRadu MoldovanuOuadii MouaqitAkutu MunyikaIonut NegoiIoannis NikolopoulosGabriela Elisa NitaMacerata HospitalCollege of Medicine and Health Sciences United Arab Emirates UniversityMaggiore HospitalQueen Elizabeth Hospital, University Hospital Birmingham NHS Foundation TrustOspedale MaggioreUniversity of California, San DiegoUniversidad del Valle, CaliHelsinki University HospitalUniversidade Estadual de CampinasPapa Giovanni XXIII HospitalGeneral SurgeryMansoura University, Faculty of MedicineAl Ain HospitalUniversity of IlorinAhmadu Bello UniversityLAUTECH Teaching HospitalMustafa Kemal UniversitesiKing Fahad Medical CityPrimary Health Care Centre of KissamosUniversity of Zagreb School of MedicineBrescia Civil HospitalHadassah University Medical CentreRegional Hospital of BizerteT. C. Saglik Bakanligi, Taksim Egitim ve Arastirma HastanesiOspedale S. ChiaraHospital de La SerenaSG Bosco HospitalNovosibirsk State Medical UniversityUniversity Hospital of LarissaCHU AngersOspedale di Città di CastelloUniversita degli Studi di Roma La SapienzaKuala Krai HospitalRegional HospitalPoliclinico Paolo GiacconeSamsun Education and Research HospitalUniversitat d'AlacantCHVNG/ETianjin Nankai HospitalEmergency Municipal Hospital PascaniAdana Numune Training and Research HospitalUniversity Clinical CenterKipshidze Central University HospitalHamad General HospitalPauls Stradins Clinical University HospitalBahrain Defence Force Royal Medical ServicesFundacao Universitaria do ABC, Faculdade de Medicina do ABCVladimir City Clinical Hospital of Emergency MedicineHospital Miguel ServetAretaieion HospitalHospital Universitário Terezinha de JesusHospital Escola Padre AlbinoAscoli Piceno HospitalTrabzon Kanuni Training and Research HospitalGovernment Medical College &amp; Hospital ChandigarhUniversity Hospital in BratislavaGeneral Hospital of KavalaMengucek Gazi Training and Research HospitalJichi Medical UniversityS. M. S. HospitalLithuanian University of Health SciencesUniversity of BelgradeTurun Yliopistollinen KeskussairaalaUniwersytet Jagiellonski w KrakowieCity HospitalInje University, College of MedicineEdendale HospitalUniversity Clinical Center of KosovoKrishna HospitalVilniaus universitetasNHS Foundation TrustUniversidade do Minho, Escola de Ciencias da SaudeYonsei University College of MedicineHospital Universitario La PazHospital Universitario DonostiaMahidol UniversityHospital Insular, Las PalmasKavala General HospitalMysore Medical CollegeCollegium Medicum Uniwersytet JagiellonskiegoTzanion General HospitalLe Scotte HospitalUniversity HospitalPandit Bhagwat Dayal Sharma Postgraduate Institute of Medical SciencesUniversity Hospital of the West IndiesSao Joao HospitalEmergency Hospital of CraiovaAristotle University of ThessalonikiCH ArmentieresNational Institute of HygieneOnandjokwe HospitalEmergency Hospital of BucharestNational Health Service2018-11-232018-11-232015-12-16World Journal of Emergency Surgery. Vol.10, No.1 (2015)174979222-s2.0-84949808332https://repository.li.mahidol.ac.th/handle/20.500.14594/36210© 2015 Sartelli et al. Background: To validate a new practical Sepsis Severity Score for patients with complicated intra-abdominal infections (cIAIs) including the clinical conditions at the admission (severe sepsis/septic shock), the origin of the cIAIs, the delay in source control, the setting of acquisition and any risk factors such as age and immunosuppression. Methods: The WISS study (WSES cIAIs Score Study) is a multicenter observational study underwent in 132 medical institutions worldwide during a four-month study period (October 2014-February 2015). Four thousand five hundred thirty-three patients with a mean age of 51.2years (range 18-99) were enrolled in the WISS study. Results: Univariate analysis has shown that all factors that were previously included in the WSES Sepsis Severity Score were highly statistically significant between those who died and those who survived (p < 0.0001). The multivariate logistic regression model was highly significant (p < 0.0001, R2 = 0.54) and showed that all these factors were independent in predicting mortality of sepsis. Receiver Operator Curve has shown that the WSES Severity Sepsis Score had an excellent prediction for mortality. A score above 5.5 was the best predictor of mortality having a sensitivity of 89.2%, a specificity of 83.5% and a positive likelihood ratio of 5.4. Conclusions: WSES Sepsis Severity Score for patients with complicated Intra-abdominal infections can be used on global level. It has shown high sensitivity, specificity, and likelihood ratio that may help us in making clinical decisions.Mahidol UniversityMedicineArticleSCOPUS10.1186/s13017-015-0055-0