Koji MatsuokaChiharu TakitaTetsuo KoyamaDaisei MiyamotoSangchai YingsakmongkonKazuya I.P.J. HidariWipawee JampangernTakashi SuzukiYasuo SuzukiKen HatanoDaiyo TerunumaGraduate School of Science and EngineeringUniversity of ShizuokaJapan Science and Technology AgencyKasetsart UniversityMahidol UniversityChubu University2018-08-242018-08-242007-07-15Bioorganic and Medicinal Chemistry Letters. Vol.17, No.14 (2007), 3826-38300960894X2-s2.0-34250351179https://repository.li.mahidol.ac.th/handle/20.500.14594/24163A conventional synthesis of α-thioglycoside of sialic acid as a glycomonomer was accomplished. Radical copolymerization of the glycomonomer with vinyl acetate proceeded smoothly to afford a new class of glycopolymers having thiosialoside residues, in which all protection was removed by a combination of transesterification and saponification to provide a water-soluble thiosialoside cluster. The results of a preliminary study on biological responses against influenza virus neuraminidases using the thiosialoside polymer as a candidate for a neuraminidase inhibitor showed that the glycopolymer has potent inhibitory activity against the neuraminidases. © 2007 Elsevier Ltd. All rights reserved.Mahidol UniversityBiochemistry, Genetics and Molecular BiologyChemistryPharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1016/j.bmcl.2007.05.016