Katie D. WhiteRiichiro AbeMichael Ardern-JonesThomas BeachkofskyCharles BouchardBruce CarletonJames ChodoshRicardo CibottiRobert DavisJoshua C. DennyRoni P. Dodiuk-GadElizabeth N. ErgenJennifer L. GoldmanJames H. HolmesShuen Iu HungMario E. LacoutureRannakoe J. LehloenyaSimon MallalTeri A. ManolioRobert G. MichelettiCaroline M. MitchellMaja MockenhauptDavid A. OstrovRebecca PavlosMunir PirmohamedElena PopeAlec RedwoodMisha RosenbachMichael D. RosenblumJean Claude RoujeauArturo P. SaavedraHajirah N. SaeedJeffery P. StruewingHirohiko SuekiChonlaphat SukasemCynthia SungJason A. TrubianoJessica WeintraubLisa M. WheatleyKristina B. WilliamsBrandon WorleyWen Hung ChungNeil H. ShearElizabeth J. PhillipsDuke-NUS Medical School SingaporeNational Yang-Ming University TaiwanChang Gung Memorial HospitalWake Forest University School of MedicineHealth Sciences Authority, Government of SingaporeVanderbilt University Medical CenterHospital for Sick Children University of TorontoMassachusetts General HospitalUniversity of Ottawa, CanadaShowa University School of MedicineNiigata University School of MedicineThe University of Alabama at BirminghamUniversity of MelbourneWake Forest University Baptist Medical CenterUniversität Freiburg im BreisgauUniversity of SouthamptonUniversite Paris 12 Val de MarneUniversity of California, San FranciscoTechnion - Israel Institute of TechnologyUniversity of LiverpoolMurdoch UniversityChildren's Mercy Hospitals and ClinicsNational Institute of Allergy and Infectious DiseasesLoyola University Medical CenterUniversity of TorontoFaculty of Medicine, Ramathibodi Hospital, Mahidol UniversityUniversity of FloridaNational Human Genome Research InstituteThe University of British ColumbiaFood and Drug AdministrationMemorial Sloan-Kettering Cancer CenterBC Children's HospitalUniformed Services University of the Health SciencesUniversity of PennsylvaniaNational Institute of Arthritis and Musculoskeletal and Skin DiseasesAustin HealthGroote Schuur HospitalHarvard Medical SchoolUniversity of Tennessee Health Science CenterLackland Air Force Base2019-08-282019-08-282018-01-01Journal of Allergy and Clinical Immunology: In Practice. Vol.6, No.1 (2018), 38-69221321982-s2.0-85041346868https://repository.li.mahidol.ac.th/handle/20.500.14594/47258© 2017 American Academy of Allergy, Asthma & Immunology Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a life-threatening, immunologically mediated, and usually drug-induced disease with a high burden to individuals, their families, and society with an annual incidence of 1 to 5 per 1,000,000. To effect significant reduction in short- and long-term morbidity and mortality, and advance clinical care and research, coordination of multiple medical, surgical, behavioral, and basic scientific disciplines is required. On March 2, 2017, an investigator-driven meeting was held immediately before the American Academy of Dermatology Annual meeting for the central purpose of assembling, for the first time in the United States, clinicians and scientists from multiple disciplines involved in SJS/TEN clinical care and basic science research. As a product of this meeting, this article summarizes the current state of knowledge and expert opinion related to SJS/TEN covering a broad spectrum of topics including epidemiology and pharmacogenomic networks; clinical management and complications; special populations such as pediatrics, the elderly, and pregnant women; regulatory issues and the electronic health record; new agents that cause SJS/TEN; pharmacogenomics and immunopathogenesis; and the patient perspective. Goals include the maintenance of a durable and productive multidisciplinary network that will significantly further scientific progress and translation into prevention, early diagnosis, and management of SJS/TEN.Mahidol UniversityMedicineReviewSCOPUS10.1016/j.jaip.2017.11.023