Tomoyuki ShiraiKim Dae JoongKazuo HakoiWitaya ThamavitChawalit PairojkulToru HoshiyaRyohei HasegawaNobuyuki ItoNagoya City University Medical SchoolMahidol UniversityKhon Kaen University2018-08-102018-08-101991-01-01Japanese Journal of Cancer Research. Vol.82, No.10 (1991), 1085-108813497006091050502-s2.0-0026002901https://repository.li.mahidol.ac.th/handle/20.500.14594/22010Praziquantel, the widely used anti‐helminthic agent, was investigated for hepatocarcinogenesis‐promoting potential using a medium‐term liver bioassay system for carcinogens. F344 male rats were given a single intraperitoneal injection of diethylnitrosamine (DEN, 200 mg/kg) and then starting 2 weeks later, received praziquantel in the diet at concentrations of 1.5 or 0.5%, or intragastrically at a dose of 1,500 mg/kg once a week for 6 weeks. Control groups received DEN or praziquantel alone. All rats were subjected to two‐thirds partial hepatectomy at week 3 and killed at week 8. Development of glutathione 5‐transferase placental form‐positive foci in the liver was significantly increased in terms of both number and area with the 1.5% dose, while only area was affected by the 0.5% dose. The results thus indicate that praziquantel at high dose has promoting potential in rat hepatocytic tumorigenesis. Copyright © 1991, Wiley Blackwell. All rights reservedMahidol UniversityBiochemistry, Genetics and Molecular BiologyMedicineArticleSCOPUS10.1111/j.1349-7006.1991.tb01761.x