Angsana PhuphuakratRobert M. ParisSorachai NittayaphanSuda LouisirirotchanakulPrasert AuewarakulMahidol UniversityArmed Forces Research Institute of Medical Sciences, Thailand2018-06-212018-06-212005-03-01Journal of Medical Virology. Vol.75, No.3 (2005), 367-373014666152-s2.0-12944265407https://repository.li.mahidol.ac.th/handle/20.500.14594/16605We showed previously that HIV-1 Rev Response Element (RRE) contains a certain degree of structural variation, and in a set of limited samples, RRE from HIV-1 natural isolates were found to have functional variability. The significance of the RRE heterogeneity is addressed further by analyzing the functional variation of RREs in a longitudinal cohort. While the RRE activity at early time points was not a good predictor of disease outcome, the RRE activity at late time points was correlated with rates of CD4+ count decline. These data suggest that RRE heterogeneity may be important in viral pathogenesis and disease progression. © 2005 Wiley-Liss, Inc.Mahidol UniversityImmunology and MicrobiologyMedicineArticleSCOPUS10.1002/jmv.20279