M. A. PfallerD. J. DiekemaM. MendezC. KibblerP. ErzsebetS. C. ChangD. L. GibbsV. A. NewellJorge FinquelievichNora TiraboschiDavid EllisDominique FramereeAnnemarie van den AbeeleJean Marc SenterreArnaldo ColomboRobert RennieSteve SancheBijie HuYingchun XuYingyuan ZhangNan Shan ZhongPilar RivasAngela RestrepoCatalina BedoutRicardo VegaMatilde MendezNada MallatovaStanislava DobiasovaJulio AyabacaJeannete ZuritaM. MallieE. CandolfiW. FegelerA. HaaseG. RodloffW. BarV. CzaikaGeorge PetrikosErzsébet PuskásIlona DocziMestyan GyulaRadka NikolovaUma BanerjeeNathan KellerVivian TullioGian Carlo SchitoGiacomo FortinaGian Piero TestoreDomenico D'AntonioGiorgio ScalisePietro MartinoGraziana MannoKee PengCelia AlpucheJose SantosEduardo Rodriguez NoriegaMussaret ZaidiJacques F.G.M. MeisEgil LingaasDanuta DzierzanowskaWaclaw PawliszynMariada Luz MartinsLuis AlbuquerqueLaura RosadoRosa VelhoJose AmorimVera N. IlinaOlga I. KretchikovaGalina A. KlyasovaSophia M. RozanovaIrina G. MultykhNikolay N. KlimkoElena D. AgapovaNatalya V. DmitrievaAbdul Mohsen Al-RasheedJan TruplLeon LangsadlAlena VaculikovaHupkova HelenaDenise RoditiAnwar HoosenH. H. Crewe-BrownM. N. Janse van RensburgAdriano DuseKyungwon LeeMi Na KimA. del PalacioAurora Sanchez-SousaJacques BilleK. MuhlethalerJen Hsien WangMalai VorachitDeniz GurVolkan KortenJohn PaulBrian JonesF. Kate GouldChris KibblerNigel WeightmanIan M. GouldUniversity of Iowa Carver College of MedicineHospital Militar Central, BogotaUCLANTSZ BAZ Megyei IntezeteNational Taiwan University HospitalGiles Scientific, Inc.Universidad de Buenos AiresHospital Escuela Gral.Women's and Children's Hospital AdelaideCHU de JumetSt. Lucas Campus Heilige FamilieCentre Hospitalier Regional de La CitadelleUniversidade Federal de Sao PauloUniversity of Alberta HospitalRoyal University HospitalZhongshan Hospital ShanghaiPeking Union Medical CollegeHuashan HospitalGuangzhou Institute of Repiratory DiseaseUniversidad Nacional de ColombiaCIBHospital Ceske BudejoviceHospital FF. AA HG1Hospital VozandesInstitut de ParasitologieWestfalische Wilhelms-Universitat MunsterRheinisch-Westfalische Technische Hochschule AachenInst. F. Med. MikrobiologieCarl-Thiem-KlinikumHumaine KlinikenLaikon General HospitalBAZ County InstituteSzegedi Tudomanyegyetem (SZTE)Pecsi TudomanyegyetemSzent Laszlo HospitalAll India Institute of Medical Sciences, New DelhiChaim Sheba Medical Center IsraelUniversita degli Studi di TorinoUniversita degli Studi di GenovaOspedale di NovaraUniversita degli Studi di Roma Tor VergataOspedale Civile di PescaraInstituto di Malattie InfettiveUniversity of MalayaHospital General de MexicoUniversidad de GuadalajaraHospital General O'HoranNijmegen Interdenominational Hospital Canisius-WilhelminaRikshospitalet-Radiumhospitalet HFInstytut Pomnik-Centrum Zdrowia DzieckaPracownia BakteriologiiUniversidade Nova de Lisboa, Instituto de Higiene e Medicina TropicalCentro Hospitalar e Universitario de CoimbraNational Research Center for HematologyHospital Geral de Santo AntonioNorth-Western State Medical University named after I.I. MechnikovInstitute of Antimicrobial ChemotherapyCity Clinical Hospital No.Territory Center of Lab DiagnosticsMedical Mycology Research InstituteIrkutsk Regional Childrens HospitalOncology Research CenterRiyadh Military HospitalNational Cancer CenterNUTaRCHDerer's University Hospital SlovakiaSt. Cyril and Method's HospitalGroote Schuur HospitalGa-Rankuwa HospitalBaragwanath HospitalUniversity of the Free StateJohannesburg HospitalYonsei University College of MedicineAsan Medical CenterHospital 12 De OctobreHospital Ramon y CajalCentre Hospitalier Universitaire VaudoisUniversitat BernChina Medical University Hospital TaichungMahidol UniversityHacettepe Children's HospitalMarmara Universitesi Tip FakultesiRoyal Sussex County HospitalGlasgow Royal InfirmaryFreeman HospitalFriarage HospitalAberdeen Royal InfirmaryLeeds General InfirmaryCardiff UniversityWayne State UniversityThe Mount Sinai Medical CenterWeill Cornell Medical CenterStanford University Medical CenterUniversity Hospitals Case Medical CenterUniversity of Texas SystemUniversity of VirginiaChristiana CareGen del Este Dr. Domingo LucianiUniversitario de Caracas2018-08-202018-08-202006-10-01Journal of Clinical Microbiology. Vol.44, No.10 (2006), 3551-3556009511372-s2.0-33947506669https://repository.li.mahidol.ac.th/handle/20.500.14594/23593Although a rare cause of invasive candidiasis, Candida guilliermondii has been reported to exhibit decreased susceptibility to antifungal agents. Aside from case reports and small surveys, there is little information regarding the epidemiology and antifungal susceptibility profile of C. guilliermondii. We report geographic and temporal trends in the isolation and antifungal susceptibilities of 1,029 C. guilliermondii clinical isolates collected from 127 medical centers as part of the ARTEMIS DISK Antifungal Surveillance Program. In addition, we report the in vitro susceptibility of 132 bloodstream isolates of C. guilliermondii to caspofungin. C. guilliermondii represented 1.4% of the 75,761 isolates collected from 2001 to 2003 and was most common among isolates from Latin America (3.7% versus 0.6 to 1.1%). Decreased susceptibility to fluconazole was noted (75% susceptible; range, 68 to 77% across regions), and voriconazole was more active in vitro against C. guilliermondii than fluconazole (91% susceptible; range, 88 to 93% across regions). Fluconazole was least active against isolates from dermatology (58%) and surgical (69%) services and against isolates associated with skin and soft tissue infection (68%, compared to 85% susceptible for bloodstream isolates). There was no evidence of increasing azole resistance over time among C. guilliermondii isolates tested from 2001 to 2003. Of 132 bloodstream isolates of C. guilliermondii tested against caspofungin, most were inhibited by ≤2 μg/ml (96%; MIC50/MIC90, 0.5/1.0 μg/ml). C. guilliermondii, a species that exhibits reduced susceptibility to fluconazole, is the sixth most frequently isolated Candida species from this large survey and may be an emerging pathogen in Latin America. Copyright © 2006, American Society for Microbiology. All Rights Reserved.Mahidol UniversityMedicineArticleSCOPUS10.1128/JCM.00865-06