Tueboon SriphojanartVasanop VachiramonMahidol University2018-11-232018-11-232015-01-01Case Reports in Dermatology. Vol.7, (2015), 100-106166265672-s2.0-84941954939https://repository.li.mahidol.ac.th/handle/20.500.14594/36701© 2015 S. Karger AG, Basel. Diffuse dermal angiomatosis (DDA) is a benign, acquired, reactive vascular proliferation. DDA is clinically characterized by painful purpuric plaque with central ulceration. The histopathologic hallmark is diffuse proliferation of endothelial cells that are arranged interstitially between collagen bundles of the reticular dermis. DDA has been reported in association with peripheral atherosclerotic disease, arteriovenous fistula and heavy smoking. We report the case of a 49-year-old Asian male with DDA who presented with a painful stellate-shaped purpuric patch on the right thigh. Histopathologic examination showed proliferation of CD34-positive spindle cells in the dermis. Our patient underwent vascular bypass surgery along with tight control of cardiovascular risk factors, which yielded successful results.Mahidol UniversityMedicineArticleSCOPUS10.1159/000430944