Sakanus VijintanawanK. C. KumarAnchisa AittiwarapojNatthamet WongsirichatMahidol UniversityWalailuk University International College of Dentistry2020-01-272020-01-272019-01-01Siriraj Medical Journal. Vol.71, No.5 (2019), 426-431222880822-s2.0-85072988466https://repository.li.mahidol.ac.th/handle/20.500.14594/52069© 2019, Siriraj Medical Journal. The combination of central odontogenic fibroma and central giant cell granuloma is extremely rare and has been reported in only 46 cases worldwide in previous articles. The lesion is called a hybrid central odontogenic fibroma with central giant cell granuloma like lesion (HCOF-CGCG) due to a histopathological characteristics of multinucleated giant cell and odontogenic epithelium in fibro-cellular background. We report a case of HCOFCGCG in a 27-year old Thai male patient who was identified as the first case in Thailand. Radiographic examination showed a well-defined radiolucency lesion at posterior mandibular area. Enucleation and curettage were done and microscopic study revealed a fibro-cellular proliferating tissue containing numerous strands, cord of odontogenic epithelium, and numerous multinucleated giant cells. This report also included a literature review of the previous 45 cases.Mahidol UniversityMedicineArticleSCOPUS10.33192/Smj.2019.63