M. L. LeimanisA. JaideeK. SriprawatS. KaewpongsriR. SuwanaruskM. BarendsA. P. PhyoB. RussellL. ReniaF. NostenShoklo Malaria Research UnitAgency for Science, Technology and Research, SingaporeMahidol UniversityJohn Radcliffe Hospital2018-09-242018-09-242010-05-01Antimicrobial Agents and Chemotherapy. Vol.54, No.5 (2010), 2228-223010986596006648042-s2.0-77951228214https://repository.li.mahidol.ac.th/handle/20.500.14594/29696The novel organometallic chloroquine analog ferroquine (SSR 97193) is effective against chloroquine-resistant Plasmodium falciparum. The ex vivo efficacy of ferroquine against Plasmodium vivax isolates was tested. Ferroquine has a potent ex vivo effect on P. vivax schizont maturation (median 50% inhibitory concentration, 15 nM; n = 42). No significant cross-sensitivity between ferroquine and other antimalarials was detected. This drug may be a suitable replacement for chloroquine in the treatment of drug-resistant P. vivax malaria. Copyright © 2010, American Society for Microbiology. All Rights Reserved.Mahidol UniversityMedicinePharmacology, Toxicology and PharmaceuticsArticleSCOPUS10.1128/AAC.01572-09