Sutatip PongcharoenPannika Niumsup RitviroolDonruedee SanguansermsriPairat ChanchanPoj JienmongkolPuntharee ButkhamchotPrateep WarnnissornNapatawn BanchuinStitaya SirisinhaNaresuan UniversityBuddhachinaraj HospitalMahidol University2018-07-122018-07-122008-03-01Asian Pacific Journal of Allergy and Immunology. Vol.26, No.1 (2008), 63-690125877X2-s2.0-45349087840https://repository.li.mahidol.ac.th/handle/20.500.14594/19753Burkholderia pseudomallei is the causative agent of melioidosis. One of the main risk factors for B. pseudomallei infection in endemic areas is diabetes mellitus. The present study investigated IL-17 mRNA and protein expression by peripheral blood mononuclear cells in response to B. pseudomallei infection in 10 diabetic patients in comparison to 10 healthy blood donors. The IL-17 expression in diabetic patients was significantly lower (p<0.05) than in the controls. However, IL-23 mRNA expression of the 2 groups was comparable. The present findings suggest that melioidosis affects T cell IL-17 production and that patients with diabetes mellitus have a defective IL-17 production in response to this type of infection.Mahidol UniversityMedicineArticleSCOPUS