Chutima KumkhaekKooruethai Phra-ekPratap SinghasivanonSornchai LooareesuwanChakrit HirunpetcharatAlan BrockmanAnne Charlotte GrünerNicolas LebrunLaurent RéniaFrançois NostenGeorges SnounouSrisin KhusmithMahidol UniversityShoklo Malaria Research UnitUniversite Paris DescartesCNRS Centre National de la Recherche Scientifique2018-07-242018-07-242004-06-01Southeast Asian Journal of Tropical Medicine and Public Health. Vol.35, No.2 (2004), 281-287012515622-s2.0-4544350026https://repository.li.mahidol.ac.th/handle/20.500.14594/21653Allelic variation in the Plasmodium falciparum circumsporozoite protein (CS) gene has been determined by sequencing the immunodominant T-cell epitopes, Th2R and Th3R, from 95 isolates from two malaria-endemic areas in the west of Thailand. Comparison with a reference sequence revealed only non-synonymous point mutations in the two epitope regions. Point mutations were found outside these epitopes in a minority of samples, and all but four were also non-synonymous. A relatively high number of variants, 11 Th2R and 9 Th3R, were detected and comprised some that had not been previously observed. However, the Th2R*05 and the Th3R*01 allelic variants predominated, as they were found in more than 70% of the 101 sequences obtained.Mahidol UniversityMedicineArticleSCOPUS