Li J.Phetcharawetch J.Qi M.Kyne S.H.Kuhakarn C.Zhong B.Chan P.W.H.Mahidol University2023-10-292023-10-292023-01-01New Journal of Chemistry (2023)11440546https://repository.li.mahidol.ac.th/handle/20.500.14594/90820A synthetic method to prepare 1-alkyl-substituted-pyrazolidin-3-ones efficiently that relies on the 4CzPN-mediated alkylation of azomethine imines by 4-alkyl-substituted-1,4-dihydropyridines (DHPs) under blue light emitting diode (LED) light (λmax = 456 nm) is reported. An approach that exploits the ability of blue LED light to initiate the acylation of the imine substrate by 4-acyl-substituted-DHPs to give 1-acyl-substituted-pyrazolidin-3-ones is also presented. Achieved under mild reaction conditions at room temperature, the synthetic protocol was shown to tolerate a broad range of functional groups to afford the corresponding 1-substituted-pyrazolidin-3-ones in yields up to 99%.Chemical EngineeringArticleSCOPUS10.1039/d3nj03780k2-s2.0-8517451098613699261